Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica

Page 22 of about 637 results

ea0017p14 | (1) | BSPED2008

Growth and pubertal status following pubertal induction in boys with IBD

Mason A , Wong S , Russell R , McGrogan P , Ahmed S

Background: Children with inflammatory bowel disease (IBD) may suffer from growth and pubertal delay.Objective: To assess pubertal status and growth in a group of boys with IBD before (T+0) and 6 months after (T+6) initiation of testosterone therapy.Methods: Retrospective study of boys with IBD undergoing pubertal induction. Height (Ht) and pubertal status were obtained at T+0 and T+6. Markers of disease activity and data on concom...
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ea0015p323 | Steroids | SFEBES2008

Antiphospholipid syndrome: a rare cause of adrenal insufficiency

Bashir Ahmed , Siddique Haroon , Moulik Probal , Macleod Andrew , Pickett Pat

Introduction: We report a case of adrenal insufficiency as the first clinical manifestation of antiphospholipid syndrome.Case report: A 56-year-old male with no previous history of thrombosis was admitted with 3 stone weight loss and feeling generally unwell. He was hypotensive, pigmented and had a slate grey pigmentation of the nose. Chest auscultation revealed reduced breath sounds. Investigations revealed low sodium and high potassium levels with meta...
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ea0013p260 | Reproduction | SFEBES2007

Serum anti-mullerian hormone is elevated in girls with exaggerated adrenarche

Paterson WF , Fleming R , Ahmed SF , Wallace AM

Anti-Mullerian hormone (AMH) is produced by the ovarian granulosa cells in immature follicles from around week 36 of gestation to the menopause. Expression is highest in pre-antral and early antral follicles. AMH has a generally inhibitory effect on early follicle development and possibly on the responsiveness of growing follicles to FSH. Serum AMH is markedly elevated in women with PCOS and increased concentrations have also been reported in the healthy prepubertal daughters ...
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ea0011p721 | Reproduction | ECE2006

Serum Anti-Mullerian hormone (AMH) concentrations in infants and children

Wilson G , Fleming R , Galloway P , Wallace AM , Ahmed SF

Introduction: AMH is produced by the sertoli cells in the testes and is responsible for the regression of the Mullerian structures in the male fetus. It is also produced by the granulosa cells of the ovaries in females to a lesser degree. Serum AMH measurements may be important for detecting testicular tissue and monitoring ovarian activity. The objective of this study was to establish a cross-sectional reference range for AMH in UK children.Method: Seru...
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ea0011p942 | Thyroid | ECE2006

Comparison of radioiodine with radioiodine plus lithium in the treatment of hyperthyroidism

Ahmed K , Nijher GMK , Banerjee A , Frank J , Meeran K

Introduction: Radioactive Iodine (RAI) is a well-established and effective treatment for hyperthyroidism. Lithium (Li) blocks the release of organic iodide and thyroid hormone from the thyroid gland without effecting thyroidal RAI uptake. Through decreasing the loss of RAI from the thyroid it has also been shown to reduce urinary RAI excretion. Its use as an adjunct to RAI in the therapy of hyperthyroidism has been postulated, but information on the subject is limited.<p c...
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ea0010p26 | Cytokines, growth factors, growth and development | SFE2005

Ahmed Z , Mazibrada G , Dent R , Berry M , Logan A

Upon binding of myelin-derived axon growth inhibitory ligands to the Nogo receptor (NgR), a complex is formed with LINGO-1 and the low affinity neurotrophin receptor p75NTR, which initiates axon growth cone collapse via a Rho-A-mediated pathway. We reasoned that, after tumor necrosis factor-α converting enzyme (TACE) cleavage of p75NTR, which triggers the initiation of regulated intramembrane proteolysis (RIP), signalling of growth cone collap...
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ea0010p96 | Thyroid | SFE2005

Comparison of radioiodine with radioiodine plus lithium in the treatment of hyperthyroidism

Ahmed K , Nijher G , Bannerjee A , Frank J , Meeran K

Introduction: Radioactive Iodine (RAI) is a well-established and effective treatment for hyperthyroidism. Lithium (Li) blocks the release of organic iodide and thyroid hormone from the thyroid gland without effecting thyroidal RAI uptake. Through decreasing the loss of RAI from the thyroid it has also been shown to reduce urinary RAI excretion. Its use as an adjunct to RAI in the therapy of hyperthyroidism has been postulated, but information on the subject is limited....
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ea0009p51 | Growth and development | BES2005

Radioimmunoassay (RIA) method for Salivary Testosterone: Reference ranges in children, adult men and adult women

Teoh Y , Macintyre H , Ahmed F , Wallace M

BackgroundThere is a need to develop a highly sensitive and reliable immunoassay method for the determination of testosterone concentrations both in children and adults. Testosterone in blood is largely bound to proteins (sex hormone binding globulin and albumin). The unbound fraction of testosterone is considered to be the biologically active hormone which correlates more closely with the physiologically effective level of this hormone. It is postulated...
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ea0008go2 | (1) | SFE2004

siRNA-Mediated Knock Down of NgR, p75NTR and Rho-A Disinhibits Neurotrophin-Induced Dorsal Root Ganglia Neurite Outgrowth on CNS Myelin

Ahmed Z , Dent RG , Suggate EL , Berry M , Logan A

Central nervous system neurones are generally incapable of regenerating their axons after injury due to the limited availability of neurotrophins, the development of a glial scar, and the presence of multiple axon growth inhibitors. We therefore designed short interfering RNA (siRNA) sequences to knock down components of the inhibitory signalling cascade and tested their ability to disinhibit the growth of FGF2-stimulated dorsal root ganglia neurone (DRGN) neurites in the pres...
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ea0007p267 | Clinical case reports | BES2004

A vicious cycle of profuse diarrhoea, hypokalaemic renal failure and elevated gut hormone levels unmasking a neuroendocrine pancreatic tumour

Yogarajah M , Ahmed A , Winocour P , Katz J , Aldridge M

A 72 year old gentleman with an eight month history of chronic, episodic diarrhoea had been investigated as an out-patient. Colonoscopy and biopsies, barium meal and follow-through, coeliac screen and thyroid function tests were all normal. He subsequently presented with an acute deterioration in diarrhoea, and severe hypokalaemia, acute renal failure and a profound metabolic acidosis. Haemofiltration and aggressive fluid management were required to compensate for gastro-intes...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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